Long-lasting discussion: Adverse effects of intraoperative blood loss and allogeneic transfusion on prognosis of patients with gastric cancer

Table 3 Systematic reviews and meta-analyses of effects of blood transfusion on prognosis in patients with gastric cancer

Study	Rate of received	Adverse effect on OS	Adverse effect on CSS	Adverse effect on RFS	Adverse effect on PCs
	BTF patients
Sun et al[1], 2015	36.3%	Yes,	Yes,	Yes,	Not specified
		HR, 2.17;	HR, 2.57;	HR, 1.52;
		95%CI, 1.86-2.37	95%CI, 1.24-5.34	95%CI, 1.08-2.15
Li et al[2], 2015	44.8%	Yes,	Not specified	Yes,	Yes,
		HR, 1.26;
				HR, 1.36;	HR, 3.33;
		95 % CI, 1.21-1.31
				95%CI, 1.02-1.81	95%CI, 1.02-1.81
Agnes et al[3], 2018	Not specified	Yes,	Yes,	Yes,	Yes,
		HR, 1.34;	HR, 1.66;	HR, 1.48;	HR, 1.36;
		95%CI, 1.23-1.45	95%CI, 1.50-2.19	95%CI, 1.18-1.86	95%CI, 2.10-5.29

BTF: Blood transfusion; OS: Overall survival; CSS: Cancer-specific survival; RFS: Relapse-free survival; PCs: Postoperative complications; HR: Hazard ratio; CI: Confidence interval.