Advanced diagnostics for pancreatic cysts: Confocal endomicroscopy and molecular analysis

doi:10.3748/wjg.v25.i22.2734

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2019; 25(22): 2734-2742
Published online Jun 14, 2019. doi: 10.3748/wjg.v25.i22.2734

Table 3 A summary of molecular biomarkers for pancreatic cysts types

Pancreatic cyst type	Molecular biomarkers
Intraductal papillary mucinous neoplasm	KRAS, GNAS, RNF43 positive[22,24,29,34,37]
Intraductal papillary mucinous neoplasm	Advanced neoplasia: TP53, SMAD4, PIK3CA, PTEN, CDKN2A, AKT1, p16, p53 positive[30-34,38,39]
Mucinous cystic neoplasm	KRAS, RNF3 positive[22,24,29,34,37]
	GNAS negative[24,28,29]
	Advanced neoplasia: TP53, SMAD4, PIK3CA, PTEN, CDKN2A, AKT1 positive[30-34]
Serious cystadenoma	VHL positive[22,24,28]
Solid papillary neoplasm	CTNNB1 positive[22,24]
Pseudocyst	Negative for DNA
Cystic neuroendocrine tumor	Not well described

Citation: Durkin C, Krishna SG. Advanced diagnostics for pancreatic cysts: Confocal endomicroscopy and molecular analysis. World J Gastroenterol 2019; 25(22): 2734-2742
URL: https://www.wjgnet.com/1007-9327/full/v25/i22/2734.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i22.2734