Systems pharmacology approach reveals protective mechanisms of Jian-Pi Qing-Chang decoction on ulcerative colitis

Figure 7 Jian-Pi Qing-Chang improves intestinal epithelial barrier function via the NF-κB/HIF-1α signalling pathway in dextran sulfate sodium-induced colitis mice. A-F: The relative protein expression in colon tissues was measured by Western blot; G: Immunofluorescence staining for Claudin-1 in colon tissues; H: The schematic diagram of therapeutic mechanism by which Jian-Pi Qing-Chang improves the mucosal inflammatory response and intestinal epithelial barrier function during the development of ulcerative colitis. Data are presented as the mean ± SD. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. JPQC: Jian-Pi Qing-Chang; DSS: Dextran sulfate sodium.