Prognostic significance of lymphovascular invasion in colorectal cancer and its association with genomic alterations

Table 2 Multivariate Cox analysis for 5-year overall survival in 1219 colorectal cancer patients

Characteristic	HR (95%CI)	P value
Gender
Male	1 (Reference)
Female	0.93 (0.77-1.13)	0.481
Age in yr
≤ 65	1 (Reference)
> 65	1.93 (1.60-2.33)	< 0.001
Tumor site
Colon	1 (Reference)
Rectum	0.94 (0.78-1.13)	0.497
Histological differentiation
Well/moderately	1 (Reference)
Poorly/mucinous	1.51 (1.24-1.85)	< 0.001
TNM stage
I	1 (Reference)
II	1.63 (1.07-2.47)	0.022
III	3.31 (2.24-4.90)	< 0.001
IV	11.88 (7.94-17.77)	< 0.001
LVI
Negative	1 (Reference)
Positive	1.77 (1.40-2.25)	< 0.001

HR: Hazard ratio; CI: Confidence interval; TNM: Tumor-node-metastasis; LVI: Lymphovascular invasion.