Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome

doi:10.3748/wjg.v25.i2.269

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2019; 25(2): 269-281
Published online Jan 14, 2019. doi: 10.3748/wjg.v25.i2.269

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Figure 3 Colonic mucosal brain-derived neurotrophic factor mRNA levels in patients with diarrhea-predominant irritable bowel syndrome and healthy controls. Mucosal brain-derived neurotrophic factor (BDNF) mRNA level is expressed as a fold-change relative to the average level of healthy controls. Diarrhea-predominant irritable bowel syndrome patients showed a significantly higher BDNF mRNA level than subjects in the control group (P = 0.001). IBS-D: Diarrhea-predominant irritable bowel syndrome; BDNF: Brain-derived neurotrophic factor.

Citation: Zhang Y, Qin G, Liu DR, Wang Y, Yao SK. Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2019; 25(2): 269-281
URL: https://www.wjgnet.com/1007-9327/full/v25/i2/269.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i2.269