Biomarker identification and trans-regulatory network analyses in esophageal adenocarcinoma and Barrett’s esophagus

Figure 2 The trans-regulatory networks of differentially expressed transcription factors and their regulatory differentially expressed genes. Circles represent the differentially expressed genes (DEGs) (red for up-regulated DEGs and green for down-regulated DEGs) regulated by the predicted transcription factor (TFs) (yellow for TFs). The direction of arrows is from the predicted TFs to their target DEGs. A: The trans-regulatory network of differentially expressed TFs and their regulatory DEGs in the comparison group of esophageal adenocarcinoma (EAC) vs normal esophagus (NE); B: The trans-regulatory network of differentially expressed TFs and their regulatory DEGs in the comparison group of Barrett's esophagus (BE) vs NE; C: The trans-regulatory network of differentially expressed TFs and their regulatory DEGs in the comparison group of EAC vs BE.