Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome

doi:10.3748/wjg.v25.i2.269

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2019; 25(2): 269-281
Published online Jan 14, 2019. doi: 10.3748/wjg.v25.i2.269

Table 3 Correlations between brain-derived neurotrophic factor level and clinical and experimental parameters in all subjects

	BDNF expression
Visceral sensitivity
First sensation threshold	-0.557 (< 0.001)^a
Defecating sensation threshold	-0.196 (0.168)
Maximum tolerable threshold	-0.453 (0.001)^a
RAIR threshold	-0.447 (0.001)^a
Mucosal nerve fiber density	0.059 (0.681)

Pearson or Spearman’s correlation coefficients are presented with P-values in parentheses.

^aP with significance after Bonferroni correction (adjusted P < 0.01). BDNF: Brain-derived neurotrophic factor; RAIR: Rectoanal inhibition reflex.

Citation: Zhang Y, Qin G, Liu DR, Wang Y, Yao SK. Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2019; 25(2): 269-281
URL: https://www.wjgnet.com/1007-9327/full/v25/i2/269.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i2.269