Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome

doi:10.3748/wjg.v25.i2.269

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2019; 25(2): 269-281
Published online Jan 14, 2019. doi: 10.3748/wjg.v25.i2.269

Table 2 Correlations between brain-derived neurotrophic factor levels and clinical and experimental parameters in patients with diarrhea-predominant irritable bowel syndrome

	BDNF expression
Clinical characteristic
Severity of abdominal pain	0.565 (0.001)^a
IBS-SSS	0.393 (0.029)^b
Visceral sensitivity
First sensation threshold	-0.562 (0.001)^a
Defecating sensation threshold	-0.015 (0.938)
Maximum tolerable threshold	-0.290 (0.113)
RAIR threshold	-0.508 (0.004)^a
Mucosal nerve fiber density	-0.058 (0.756)

Spearman’s correlation coefficients are presented with P-values in parentheses.

^aP with significance after Bonferroni correction (adjusted P < 0.0071).

^bP without significance after Bonferroni correction (adjusted P < 0.0071). BDNF: Brain-derived neurotrophic factor; IBS-SSS: IBS Symptom Severity Scale; RAIR: Rectoanal inhibition reflex.

Citation: Zhang Y, Qin G, Liu DR, Wang Y, Yao SK. Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2019; 25(2): 269-281
URL: https://www.wjgnet.com/1007-9327/full/v25/i2/269.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i2.269