Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome

doi:10.3748/wjg.v25.i2.269

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 25, Issue 2

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (8819)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-3) series.

Item

Count

PDF

555

WORD

311

HTML

4166

Figures (1-3)

247

Tables (1-3)

250

Sum=5529

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1139

Download

2151

Sum=3290

Jan 14, 2019 (publication date) through Nov 9, 2024

Times Cited of This Article

Times Cited (32)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Gastroenterol. Jan 14, 2019; 25(2): 269-281
Published online Jan 14, 2019. doi: 10.3748/wjg.v25.i2.269

Table 2 Correlations between brain-derived neurotrophic factor levels and clinical and experimental parameters in patients with diarrhea-predominant irritable bowel syndrome

	BDNF expression
Clinical characteristic
Severity of abdominal pain	0.565 (0.001)^a
IBS-SSS	0.393 (0.029)^b
Visceral sensitivity
First sensation threshold	-0.562 (0.001)^a
Defecating sensation threshold	-0.015 (0.938)
Maximum tolerable threshold	-0.290 (0.113)
RAIR threshold	-0.508 (0.004)^a
Mucosal nerve fiber density	-0.058 (0.756)

Spearman’s correlation coefficients are presented with P-values in parentheses.

^aP with significance after Bonferroni correction (adjusted P < 0.0071).

^bP without significance after Bonferroni correction (adjusted P < 0.0071). BDNF: Brain-derived neurotrophic factor; IBS-SSS: IBS Symptom Severity Scale; RAIR: Rectoanal inhibition reflex.

Citation: Zhang Y, Qin G, Liu DR, Wang Y, Yao SK. Increased expression of brain-derived neurotrophic factor is correlated with visceral hypersensitivity in patients with diarrhea-predominant irritable bowel syndrome. World J Gastroenterol 2019; 25(2): 269-281
URL: https://www.wjgnet.com/1007-9327/full/v25/i2/269.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i2.269