Biomarker identification and trans-regulatory network analyses in esophageal adenocarcinoma and Barrett’s esophagus

Table 2 Differentially expressed genes in the trans-regulatory networks existed in both GSE1420 and GSE26886 datasets

Comparison group	Up-regulated DEGs	Down-regulated DEGs
EAC vs NE	UCP2, TOP1, TIMP1, TAP1, STAT11, ST6GAL1, SOCS1, SMURF2, SLC19A1, SKIL, SERPINE1, SDC4, RELB1, RARRES3, PTPN6, PSMB9, PRKCA, PPARG1, PLAUR, PLAU, PECAM1, PDGFA, ODC1, NT5E, NR1H3, NQO1, MYBL21, MUC5AC, MTRR, MMP9, MMP7, MET, MAN2B1, LAMB1, ITGB1, ITGAV, IRF3, IRF1, IGFBP3, ICAM1, HSD17B2, HOXB71, HMGA2, HFE, HEXB, HEXA, GUSB, GBP1, GALC, F2R, ENG, EGR11, DSG2, CXCL1, COL5A2, COL1A2, COL1A1, CFTR, CD14, ATP2A3, APOE, ADAM28, A2M	TOM1, TGM1, TGFA, TFAP2C1, TFAP2A1, TALDO1, SRPX2, SNAI2, SMARCA2, SMAD21, SLC6A4, SLC13A4, SERPINB2, RORA1, RARG1, PRNP, PPL, PIM1, PEX3, PBX1, OAT, MAPT, MAPK1, LMO2, KRT5, KRT4, KRT16, KRT14, IMPA2, HSPB1, HRAS, HOXA41, HMOX1, HLF1, GSTP1, GM2A, GLUD1, FLG, FGFR3, FCER1A, ETF1, DSG3, DSG1, DBI, CYP11A1, CSTA, CRABP2, CEACAM1, CALB2, BCKDHA, ATP12A, ALDH3A2, AKR1C1, AGA, ADIPOR1, ACOX1, ACAA1
BE vs NE	UCP2, TIMP1, TGFBR2, SOCS3, REG1A, PPARG1, PLAUR, NR1H3, NQO1, MMP1, KRT18, GDF15, GBP1, FOS1, CA2, ANPEP, A2M	RORA, HOXA11, FCER1A, CYP11A1, BMP7

¹Differentially expressed transcription factors. DEGs: Differentially expressed genes; EAC: Esophageal adenocarcinoma; NE: Normal esophagus; BE: Barrett's esophagus.