Biomarker identification and trans-regulatory network analyses in esophageal adenocarcinoma and Barrett’s esophagus

doi:10.3748/wjg.v25.i2.233

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2019; 25(2): 233-244
Published online Jan 14, 2019. doi: 10.3748/wjg.v25.i2.233

Table 1 Differentially expressed transcription factors in the comparison groups in the GSE1420 dataset

Comparison group	Up-regulated TFs	Down-regulated TFs
EAC vs NE	ATF3, ATF5, CEBPB, E2F3¹, EGR1, EGR3, EGR4, FOXA2¹, HOXA10, HOXB7¹, MYBL2, NFIB, PPARG, RELB, SMAD6, SP3, STAT1	PAX9¹, RARG, SMAD2, TFAP2A, TFAP2B, TFAP2C¹, FOXE1, HLF, HOXA4, HOXB2
BE vs NE	ATF3, E2F3¹, EPAS1, ETS2, FOS, FOSB, FOXA2¹, HOXB7¹, NFIB, PPARG, STAT1	PAX9¹, TFAP2B, TFAP2C¹, HLF, HOXA1, HOXA4
EAC vs BE	E2F3¹, EGR4, FOXA2¹, HOXA10, HOXB7¹, MYBL2	PAX9¹, PPARD, RARG, TFAP2C¹, ELK3, ETS2, FOXE1

¹Differentially expressed transcription factors, which displayed the same expression tendency among all the three comparison groups. TF: Transcription factor; EAC: Esophageal adenocarcinoma; NE: Normal esophagus; BE: Barrett's esophagus.

Citation: Lv J, Guo L, Wang JH, Yan YZ, Zhang J, Wang YY, Yu Y, Huang YF, Zhao HP. Biomarker identification and trans-regulatory network analyses in esophageal adenocarcinoma and Barrett’s esophagus. World J Gastroenterol 2019; 25(2): 233-244
URL: https://www.wjgnet.com/1007-9327/full/v25/i2/233.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i2.233