Six-long non-coding RNA signature predicts recurrence-free survival in hepatocellular carcinoma

doi:10.3748/wjg.v25.i2.220

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2019; 25(2): 220-232
Published online Jan 14, 2019. doi: 10.3748/wjg.v25.i2.220

Table 2 Univariate and multivariate Cox regression analyses of clinicopathologic characteristics associated with recurrence in The Cancer Genome Atlas samples

Variable	Univariate analysis		Multivariate analysis
Variable	HR (95%CI)	P-value	HR (95%CI)	P-value
Six-lncRNA risk score	1.341 (1.110-1.620)	0.002^a	1.270 (1.018-1.585)	0.034^a
TNM stage (IV/III/II/I)	1.727 (1.441-2.070)	< 0.001^a	1.705 (1.393-2.089)	< 0.001^a
Gender (male/female)	0.982 (0.711-1.355)	0.911	-	-
Age (> 60/≤ 60)	0.956 (0.707-1.294)	0.773	-	-
HBV (yes/no)	0.804 (0.505-1.281)	0.359	-	-
HCV (yes/no)	1.271 (0.798-2.207)	0.313	-	-
Alcohol consumption (yes/no)	1.062 (0.769-1.467)	0.717	-	-
Liver cirrhosis (yes/no)	1.271 (0.861-1.877)	0.228	-	-
Albumin (> 3.5/≤ 3.5 g/dL)	0.968 (0.659-1.424)	0.870	-	-
Creatinine (≥ 1.1/< 1.1 mg/dA)	0.739 (0.511-1.069)	0.109	-	-
AFP (> 20/≤ 20 ng/mL)	1.380 (0.972-1.959)	0.072
Platelet (> 250/≤ 250 × 10⁹/L)	1.314 (0.932-1.854)	0.119	-	-
Race (Asian/White)	1.270 (0.928-1.739)	0.136	-	-
BMI (≥ 24/< 24)	0.860 (0.697-1.062)	0.161	-	-
Family history (yes/no)	0.920 (0.655-1.292)	0.630	-	-
ECOG (> 0/0)	1.858 (1.329-2.598)	< 0.001^a	1.486 (1.045-2.114)	0.028^a
TP53 mutation (yes/no)	1.389 (1.004-1.922)	0.047^a	1.326 (0.894-1.967)	0.161

^aStatistically significant. AFP: Alpha-fetoprotein; BMI: Body mass index; ECOG: Eastern Cooperative Oncology Group; HR: Hazard ratio; HBV: Hepatitis B virus; HCV: Hepatitis C virus.

Citation: Gu JX, Zhang X, Miao RC, Xiang XH, Fu YN, Zhang JY, Liu C, Qu K. Six-long non-coding RNA signature predicts recurrence-free survival in hepatocellular carcinoma. World J Gastroenterol 2019; 25(2): 220-232
URL: https://www.wjgnet.com/1007-9327/full/v25/i2/220.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i2.220