Prevention of overuse: A view on upper gastrointestinal endoscopy

Table 3 Description of studies using a Helicobacter pylori test and treat strategy to reduce upper gastrointestinal endoscopies

Study	Country	Sample	Strategy	No endoscopy after HP test and treat
Hu et al[43], 2006	China	161 patients	UGIE vs HP testing (UBT) + eradication (HP+) or Cisapride (HP-).	Symptom relief: 44%. Endoscopy for all after 6 weeks.
Mahadeva et al[44], 2008	Malaysia	432 patients	UGIE vs HP testing (UBT) + eradication (HP+) or reassurance and/or empirical treatment (HP-)	89%
Arents et al[45], 2003	Netherlands	270 patients	UGIE vs HP testing (serology) + eradication (HP+) or Cisapride (HP-)	68%
Laheij et al[46], 2004	Netherlands	199 patients	UGIE vs omeprazole 2 wk followed by UGIE (no improvement) or HP serology testing (relapse) + eradication (HP+)	94%
Duggan et al[47], 2008	United Kingdom	584 patients	UGIE vs HP test + endoscopy (HP+) vs HP testing (serology) + eradication and/or endoscopy (HP+) or Lanzoprazole (HP-).	73%
Heaney et al[49], 1999	United Kingdom	104 patients	All received HP testing (UBT). Randomization of HP+ patients: UGIE or eradication therapy.	73%
McColl et al[50], 2002	United Kingdom	708 patients	UGIE vs HP testing (UBT) + eradication (HP+).	92%
Lassen et al[51], 2000	Denmark	500 patients	UGIE vs HP testing (UBT) + eradication (HP+), PPI (HP-, NSAID-, reflux+), or lifestyle advice (HP-, NSAID-, reflux-)	60%
Fraser et al[48], 2003	New Zealand	173 patients	All received UBT and eradication if HP+	76%
Slade et al[53], 1999	United Kingdom	232 patients	All received HP serology testing + UGIE (HP equivocal), eradication (HP+), or usual care (HP-).	73%
Patel et al[54], 1995	United Kingdom	183 patients	All received serology testing + UGIE for HP+, sinister symptoms, or NSAID use.	37% (after HP-)

UGIE: Upper gastrointestinal endoscopy; HP: Helicobacter pylori; UBT: Urea breath test, NSAID: Nonsteroidal anti-inflammatory drugs.