Current status, problems, and perspectives of non-alcoholic fatty liver disease research

doi:10.3748/wjg.v25.i2.163

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2019; 25(2): 163-177
Published online Jan 14, 2019. doi: 10.3748/wjg.v25.i2.163

Table 3 Novel therapeutic agents for non-alcoholic fatty liver disease/ non-alcoholic steatohepatitis under clinical trials

Target	Agent	Action	Clinical trial
Diabetes, insulin resistance	Semaglutide	DPP4 inhibitor	Phase II
	Gliflozin	SGLT2 inhibitor[89]	Pilot
	BMS-986036	Recombinant FGF21[90]	Phase II
Dyslipidemia	Aramchol	SCD inhibitor	Phase II
Dyslipidemia	GS-0976	ACC inhibitor	Phase II
Nuclear receptor	Obeticholic acid	FXR agonist[84]	Phase III
	Elafibranor	PPARα/δ agonist[85]	Phase III
	MGL-3196	TRβ agonist	Phase II
Apoptosis	Emricasan	Pan-caspase inhibitor[91]	Phase II
Inflammation, fibrosis	Selonsertib	ASK1 inhibitor[87]	Phase III
	Cenicriviroc	CCR2/5 antagonist[88]	Phase III
	JKB-121	TLR4 antagonist	Phase II
	GR-MD-02	Galectin 3 inhibitor[92]	Phase II
	ND-LO2-s0201	HSP47 siRNA[93]	Phase I

Citation: Tanaka N, Kimura T, Fujimori N, Nagaya T, Komatsu M, Tanaka E. Current status, problems, and perspectives of non-alcoholic fatty liver disease research. World J Gastroenterol 2019; 25(2): 163-177
URL: https://www.wjgnet.com/1007-9327/full/v25/i2/163.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i2.163