High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis

doi:10.3748/wjg.v25.i19.2383

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

World J Gastroenterol. May 21, 2019; 25(19): 2383-2401
Published online May 21, 2019. doi: 10.3748/wjg.v25.i19.2383

Table 7 Diagnostic accuracy parameters for advanced neoplasia detection based on quantitative faecal immunochemical test for haemoglobin threshold concentration and brand

Brand	Threshold(µg/g faeces)	Author, year	Sensitivity¹	Specificity¹
Mixed cohorts
OC-Sensor^®	5	Ou, 2013[21]	56.8 (39.5-72.9)	88.7 (85.7-91.2)
OC-Sensor^®	25	Rozen, 2010[17]	27.5 (20.3-34.7)	96.7 (95.8-97.6)
OC-Sensor^®	25	Terhaar sive Droste, 2010[32]	48.3 (42.6-53.9)	94.3 (93.2-95.3)
OC-Sensor^®	30	Rozen, 2010[17]	26.8 (19.9-34.7)	97.3 (96.5-98.1)
OC-Sensor^®	30	Terhaar sive Droste, 2010[32]	46.0 (40.4-51.7)	95.1 (94.1-96.1)
OC-Sensor^®	40	Rozen, 2010[17]	26.2 (19.1-33.2)	97.8 (97.0-98.5)
OC-Sensor^®	40	Terhaar sive Droste, 2010[32]	43.2 (37.6-48.9)	95.8 (94.8-96.7)
HM-JACKarc^®	LoD	Auge, 2016[22]	96.6 (82.8-93.4)	10.6 (6.9-15.9)
HM-JACKarc^®	10	Auge, 2016[22]	34.5 (19.9-52.7)	87.2 (81.6-91.3)
HM-JACKarc^®	20	Auge, 2016[22]	31.0 (17.3-49.2)	92.8 (88.0-95.7)
HM-JACKarc^®	30	Auge, 2016[22]	31.0 (17.3-49.2)	93.3 (88.7-96.1)
HM-JACKarc^®	40	Auge, 2016[22]	27.6 (14.7-45.7)	93.9 (89.4-96.6)
FOB Gold^®	10	Auge, 2018[30]	45.7 (33.7-58.1)	84.7 (80.8-88.0)
FOB Gold^®	20	Auge, 2018[30]	37.1 (26.1-49.6)	87.9 (84.2-90.8)
FOB Gold^®	30	Auge, 2018[30]	35.7 (24.6-48.1)	90.3 (87.0-93.1)
FOB Gold^®	40	Auge, 2018[30]	32.9 (22.4-45.2)	91.1 (87.8-93.6)
FOB Gold^®	50	Auge, 2018[30]	31.4 (20.9-43.6)	92.3 (89.3-94.7)
FOB Gold^®	60	Auge, 2018[30]	30.0 (19.9-42.3)	92.3 (89.2-94.6)
100% symptomatic
HM-JACK^®	20	Parente, 2012[24]	35.6 (27.9-44.1)	94.5 (89.7-97.2)

¹Values are expressed as percentages and its 95% confidence interval.

Citation: Pin Vieito N, Zarraquiños S, Cubiella J. High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis. World J Gastroenterol 2019; 25(19): 2383-2401
URL: https://www.wjgnet.com/1007-9327/full/v25/i19/2383.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i19.2383