High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis

doi:10.3748/wjg.v25.i19.2383

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World Journal of Gastroenterology

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1007-9327

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Meta-Analysis

World J Gastroenterol. May 21, 2019; 25(19): 2383-2401
Published online May 21, 2019. doi: 10.3748/wjg.v25.i19.2383

Table 4 Diagnostic accuracy parameters for colorectal cancer detection based on quantitative faecal immunochemical test for haemoglobin threshold concentration and brand

Brand	Threshold(µg/g faeces)	Author, year	Sensitivity¹	Specificity¹
Mixed cohorts
OC-Sensor^®	25	Rozen, 2010[17]	60.0 (36.1-80.9)	95.2 (94.0-96.2)
OC-Sensor^®	30	Rozen, 2010[17]	55.0 (31.5-76.9)	95.8 (94.7-96.7)
OC-Sensor^®	40	Rozen, 2010[17]	55.0 (31.5-76.9)	96.3 (95.3-97.2)
OC-Sensor^®	40	van Turenhout, 2014[18]	75.4 (63.5-84.9)	94.8 (93.9-95.6)
OC-Sensor^®	60	Symonds 2016[23]	63.6 (50.9-75.1)	91.9 (90.3-93.3)
OC-Sensor^®	80	Symonds 2016[23]	59.1 (46.3-71.0)	93.4 (91.9-94.7)
HM-JACK^®	33	Woo, 2005[19]	50.0 (11.8-88.2)	83.5 (73.5-90.9)
FOB Gold^®	10	Auge, 2018[30]	91.7 (71.5-98.5)	82.2 (79.6-84.5)
FOB Gold^®	20	Auge, 2018[30]	87.5 (66.5-96.7)	86.0 (83.6-88.1)
FOB Gold^®	30	Auge, 2018[30]	83.3 (61.8-94.5)	89.2 (87.0-91.1)
FOB Gold^®	40	Auge, 2018[30]	83.3 (61.8-94.5)	90.3 (88.2-92.1)
FOB Gold^®	50	Auge, 2018[30]	83.3 (61.8-94.5)	91.4 (89.4-93.1)
FOB Gold^®	60	Auge, 2018[30]	83.3 (61.8-94.5)	91.8 (89.9-93.5)
100% Symptomatic
HM-JACK^®	20	Parente, 2012[24]	61.7 (46.4-75.5)	88.8 (84.1-92.6)
HM-JACKarc^®	7	Widlak, 2017[28]	84.0 (63.9-95.5)	93.1 (90.2-95.4)

¹Values are expressed as percentages and its 95% confidence interval.

Citation: Pin Vieito N, Zarraquiños S, Cubiella J. High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis. World J Gastroenterol 2019; 25(19): 2383-2401
URL: https://www.wjgnet.com/1007-9327/full/v25/i19/2383.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i19.2383