High-risk symptoms and quantitative faecal immunochemical test accuracy: Systematic review and meta-analysis

Table 2 Possibility of data extraction on the accuracy of quantitative faecal immunochemical test for haemoglobin for detecting colorectal cancer, advanced neoplasia and significant colonic lesion

Study	CRC							AN						SCL
	Threshold (U)					SxD	SD	Threshold (U)					SxD	Threshold (U)					SxD
	0	10	15	20	Other			0	10	15	20	Other		0	10	15	20	Other
Rozen, 2010[17]		x	x	x	25; 30; 40				x	x	x	25; 30; 40
Van Turenhout, 2014[18]		x	x	x	40	x
Mc Donald, 2012[20]		x							HRA						x
Ou, 2013[21]					5							5; HRA
Symonds, 2016[23]		x			60; 80		x
Auge, 2016[22]								x	x		x	30; 40	x
Woo, 2005[19]					33							3; HRA
Auge, 2018[30]		x		x	30; 40; 50; 60		x		x		x	30; 40; 50; 60			x		x	30; 40; 50; 60
Cubiella, 2014 (DC)[29]	x	x	x	x		x		x	x	x	x		x	x	x	x	x		x
Cubiella, 2016 (VC)[31]	x	x	x	x		x		x	x	x	x		x	x	x	x	x		x
Rodríguez-Alonso 2015[25]	x	x	x	x				x	x	x	x
Mowat, 2016[26]	x	x						HRA	HRA					x	x
Parente, 2012[24]				x							x
Godber, 2016[27]															x	x	x	25; 30; 35; 40
Widlack, 2017[28]																		7; HGD

AN: Advanced neoplasia; CRC: Colorectal cancer; DC: Derivation cohort; HDG: High-grade dysplasia; HRA: High risk adenoma; SCL: Significant colonic lesion; SxD and SD: Differences between sex and stage respectively can be calculated VC: Validation cohort; (U): Threshold units: μgrams of haemoglobin per gram of faeces.