Change in arterial tumor perfusion is an early biomarker of lenvatinib efficacy in patients with unresectable hepatocellular carcinoma

doi:10.3748/wjg.v25.i19.2365

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 21, 2019; 25(19): 2365-2372
Published online May 21, 2019. doi: 10.3748/wjg.v25.i19.2365

Table 3 The performance characteristics of the rate of change of time-intensity curve parameters for the prediction of responders

	Slope (95%CI)	TTP (95%CI)	AUC (95%CI)
AUROC	0.818 (0.602-0.944)	0.869 (0.728-0.975)	0.939 (0.812-0995)
Cut-off value (%)	-11.765	+9.495	-25.714
Sensitivity	0.889 (0.540-0.978)	0.889 (0.540-0.978)	0.896 (0.616-0.989)
Specificity	0.545 (0.304-0.786)	0.818 (0.510-0.917)	0.909 (0.648-0.995)
PPV	0.615 (0.583-0.793)	0.800 (0.611-0.907)	0.833 (0.727-0.918)
NPV	0.857 (0.731-0.922)	0.878 (0.741-0.962)	0.900 (0.747-0.992)

TIC: Time-intensity curve; CI: Confidence interval; TTP: Time to peak; AUC: Area under the curve; AUROC: Area under receiver operating curve; PPV: Positive predictive value; NPV: Negative predictive value.

Citation: Kuorda H, Abe T, Fujiwara Y, Okamoto T, Yonezawa M, Sato H, Endo K, Oikawa T, Sawara K, Takikawa Y. Change in arterial tumor perfusion is an early biomarker of lenvatinib efficacy in patients with unresectable hepatocellular carcinoma. World J Gastroenterol 2019; 25(19): 2365-2372
URL: https://www.wjgnet.com/1007-9327/full/v25/i19/2365.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i19.2365