Risk factors for progression to acute-on-chronic liver failure during severe acute exacerbation of chronic hepatitis B virus infection

Table 3 Univariate and multivariate analyses of risk factors associated with post-admission progression to hepatic decompensation

Variable	Univariate analysis				Multivariate analysis
	Β	OR	95%CI	P-value	β	OR	95%CI	P-value
Age	0.077	1.080	1.038-1.123	0.000
HBV DNA	-0.276	0.759	0.587-0.981	0.035
ALT	-0.002	0.998	0.997-0.999	0.000	-0.003	0.997	0.995-1.000	0.038
AST	-0.001	0.999	0.998-1.000	0.015
CHE	-0.599	0.549	0.405-0.744	0.000
ALB	-0.140	0.869	0.796-0.948	0.002
BUN	0.238	1.268	1.029-1.563	0.026
PLT	-0.014	0.986	0.977-0.995	0.003
LC	5.019	151.2	19.6-1167.6	0.000	5.040	154.5	16.2-1469.0	0.000

CI: Confidence interval; OR: Odds ratio; ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BUN: Urea nitrogen; CHE: Cholinesterase; HD: Hepatic decompensation; MELD: Model for end-stage liver disease; PLT: Platelet.