Mechanism of exosomal microRNA-224 in development of hepatocellular carcinoma and its diagnostic and prognostic value

Figure 3 MicroRNA-224 targets glycine N-methyltransferase. A: MicroRNA-224 (MiR-224) mimic reduced the luciferase activity of cells transfected with the wild-type 3’-UTR but did not alter the luciferase activity of cells transfected with the mutant 3’-UTR. B: Si-glycine N-methyltransferase (siGNMT) can promote cell growth as measured by the Cell Counting Kit 8 assay in HepG2 cells. C: SiGNMT can promote cell invasion in HepG2 cells. ^bP < 0.01. CCK8: Cell Counting Kit 8; miR-224: MicroRNA-224; GNMT: Glycine N-methyltransferase.