Repurposing drugs to target nonalcoholic steatohepatitis

Table 2 Associations between variants in locus that are targets of novel drugs for the treatment of nonalcoholic steatohepatitis and multiple traits from individuals of the United Kindom Biobank

Trait	Variant	Position	-log10(p-value)
NR1H4 (FXR) Farnesoid X-Activated Receptor
K85 Acute pancreatitis	rs76372051	100945711	6.963890333
Immature reticulocyte fraction	rs35712	100971355	5.607954097
Impedance of arm (right)	rs1409791	100851307	5.152661824
Impedance of whole body	rs1409791	100851307	4.772216099
migraine	rs12579460	100966714	4.639293011
high cholesterol	rs7967468	100853792	4.543497322
N30-N39 Other diseases of urinary system	rs79306023	100938470	4.420628035
H81 Disorders of vestibular function	rs140644635	100923359	4.069764347
PPARδ (Peroxisome Proliferator Activated Receptor Delta)
Whole body fat-free mass	rs36018387	35386872	59.74853212
Hip circumference	rs36018387	35386872	49.20670564
Whole body fat mass	rs36018387	35386872	37.00113934
Body fat percentage	rs36018387	35386872	20.45328464
Monocyte percentage	rs9469982	35267548	45.86340625
Platelet crit	rs33959228	35259397	21.6726615
White blood cell (leukocyte) count	rs9380500	35266231	21.54556677
Platelet count	rs9658111	35364534	17.88276186
Neutrophill count	rs9380500	35266231	17.11253462
Eosinophill percentage	rs2395625	35405461	15.34904201
Lymphocyte percentage	rs9658079	35327577	9.741626151
asthma	rs1557568	35260530	9.184130164
K90 Intestinal malabsorption	rs7771474	35320447	11.86097145
MPC1 (Mitochondrial Pyruvate Carrier 1)
Mean platelet (thrombocyte) volume	rs10946160	166757818	7.378512135
Platelet count	rs3728	166778679	5.285527735
Red blood cell (erythrocyte) count	rs6916128	166759313	4.825911105
M31 Other necrotising vasculopathies	rs7449594	166774429	4.699926505
dyspepsia / indigestion	rs6909951	166758198	4.594790286
MAP3K5 (ASK-1) (Mitogen-Activated Protein Kinase Kinase Kinase 5)
Mean platelet (thrombocyte) volume	rs6924387	137082948	14.48853109
Eosinophill count	rs932589	137083138	13.39556873
Lymphocyte percentage	rs6924387	137082948	10.84396601
Neutrophill count	rs6924387	137082948	10.59715422
Platelet count	rs9321570	137095679	9.792150289
White blood cell (leukocyte) count	rs6924387	137082948	9.574319083
Eosinophill percentage	rs932589	137083138	9.344890391
Monocyte count	rs9385775	137144920	9.1157769
Mean reticulocyte volume	rs9385775	137144920	8.817927896
Platelet distribution width	rs6924387	137082948	8.001963098
THRβ (Thyroid Hormone Receptor Beta)
Mean corpuscular volume	rs869785	24347800	152.2743497
Mean corpuscular haemoglobin	rs869784	24348008	143.9371173
Red blood cell (erythrocyte) count	rs869785	24347800	61.9076303
Mean reticulocyte volume	rs869784	24348008	43.97976306
Reticulocyte count	rs1505307	24343330	16.57632823
Immature reticulocyte fraction	rs869784	24348008	15.67096843
Monocyte count	rs12485694	24346109	11.11788547
Lymphocyte count	rs13096529	24232035	10.58643203
Red blood cell (erythrocyte) distribution width	rs2167115	24339734	10.44361306
C56 Malignant neoplasm of ovary	rs189397255	24389732	12.2277003
Trunk fat-free mass	rs13100197	24491484	8.731024419
Trunk predicted mass	rs13100197	24491484	8.614769205
Leg fat percentage (left)	rs1349265	24159387	8.323233252

The associations have been computed using 452264 United Kindom Biobank White British individuals. http://geneatlas.roslin.ed.ac.uk/.