Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma

Figure 2 Expression of differentially expressed genes in senescent cells. A: The differentially expressed genes were identified in replicative senescence (RS) and oncogene-induced senescence (OIS) models. There were 781 up-regulated and 739 down-regulated genes selected using the RS model, and 103 up-regulated and 288 down-regulated genes selected using the OIS model; B: Overlapping the two lists, 42 common differentially expressed genes were selected as senescence associated genes; C: The expression levels of 42 genes are presented as a heat map in RS and OIS models. DEGs: Differentially expressed genes; RS: Replicative senescence; OIS: Oncogene-induced senescence; SAGs: Senescence associated genes; FC: Fold change; LASSO: Least absolute shrinkage and selection operator.