Clinical characteristics of non-alcoholic fatty liver disease in Chinese adult hypopituitary patients

Table 1 Clinical characteristics of hypopituitary patients with or without non-alcoholic fatty liver disease

	NAFLD (-) (n = 23)	NAFLD (+)
		NAFLD (n = 20)	Cirrhosis (n = 7)
Male n (%)	17 (73.9)	13 (65.0)	6 (85.7)
Age (yr)	22.8 (19.6-30.4)	30.8 (24.5-34.6)	21.0 (19.0-25.2)
Duration (yr)	3.0 (1.0-13.0)a	8.5 (1.1-19.0)	13.0 (11.0-18.0)
BMI (kg/m2)	22.2 (19.3-25.3)a	27.9 (25.4-31.7)	27.7 (24.2-32.1)
WC (cm)	73.0 (81.5-96.3)a	102.0 (92.5-109.8)	110.5 (91.5-128.8)
SBP (mmHg)	108.7 ± 15.3	122.0 ± 13.4	108.4 ± 15.5
DBP (mmHg)	70.0 ± 12.5	77.1 ± 11.1	64.4 ± 8.1
GH (ng/mL)	0.10 (0.05-0.30)	0.10 (0.08-0.10)	0.10 (0.05-0.25)
IGF1 (ng/mL)	66.0 (28.0-113.0)	107.0 (43.0-141.0)	92.5 (25.0-205.3)
FT3 (pg/mL)	2.61 (2.24-3.15)	2.43 (2.25-3.08)	2.53 (2.15-2.72)
FT4 (ng/dL)	0.86 (0.66-1.01)	0.88 (0.70-1.11)	0.97 (0.46-1.14)
TSH (μIU/mL)	1.907 (0.151-2.968)	2.098 (0.806-2.557)	3.083 (0.091-4.945)
GLU (mmol/L)	5.0 (4.6-5.3)	4.9 (4.5-5.3)	5.3 (4.7-8.9)
HOMA-IR	2.60 (1.60-3.71)a	3.92 (2.62-6.02)	9.57 (2.23-10.94)
HbA1C (%)	5.2 (4.7-5.5)	5.5 (5.3-5.9)	6.7 (4.7-8.8)
TC (mmol/L)	4.98 (4.18-5.74)	5.07 (4.70-7.03)	5.31 (4.55-6.16)
TG (mmol/L)	1.29 (0.98-1.78)	1.89 (1.06-2.48)	2.15 (1.16-2.89)
HDL-C (mmol/L)	1.17 (0.97-1.44)	0.99 (0.89-1.49)	0.93 (0.70-1.41)
LDL-C (mmol/L)	2.91 ± 0.97	3.29 ± 1.08	3.34 ± 0.72
UA (μmol/L)	418.91 ± 88.25	457.42 ± 111.01	493.14 ± 212.83
hsCRP (mg/L)	2.07 (1.14-5.24)	3.43 (2.27-6.68)	2.28 (1.50-13.71)
Posm (mOsm/kgH2O)	305.2 (298.8-314.6)	299.3 (293.7-305.5) b	314.9 (296.0-336.1)
Na (mmol/L)	146.0 (143.0-150.0)	143.0 (140.0-146.5) b	151.0 (141.0-162.0)
Cl (mmol/L)	109.0 (108.0-114.0)	106.0 (104.3-110.8) b	118.0 (108.0-130.0)
K (mmol/L)	4.20 ± 0.30	4.10 ± 0.30	4.10 ± 0.20
Cr (μmol/L)	66.8 ± 15.2	70.2 ± 16.9	64.4 ± 17.0

^aP < 0.05 vs the cirrhosis group.

^bP < 0.05 vs the cirrhosis group.

NAFLD: Non-alcoholic fatty liver disease; BMI: Body mass index; WC: Waist circumference; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; GH: Growth hormone; IGF1: Insulin like growth factor 1; FT₃: Free triiodothyronine; FT₄: Free thyroxine; TSH: Thyroid stimulating hormone; GLU: Glucose; HOMA-IR: Homeostasis model assessment of insulin resistance; HbA1_C: Glycated hemoglobin A1_C; TC: Total cholesterol; TG: Triglyceride; HDL-C: High density lipoprotein cholesterol; LDL-C: Low density lipoprotein cholesterol; UA: Uric acid; hsCRP: Hypersensitive C reactive protein; Posm: Plasma osmolality; Na: Serum sodium; K: Serum potassium; Cl: Serum chlorine; Cr: Serum creatinine.