Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma

Table 2 Stratified analysis of overall survival in GSE14520 and The Cancer Genome Atlas cohorts

Variable	Discovery cohort			Validation cohort-Asian only
	High-risk/low-risk	HR (95%CI)	P-value	High-risk/low-risk	HR (95%CI)	P-value
Overall	76/75	1.92 (1.16-3.19)	0.011a	79/78	5.81 (3.20-10.54)	< 0.001a
Gender
Male	69/67	2.15 (1.27-3.64)	0.004a	62/61	5.18 (2.66-10.10)	< 0.001a
Female	7/8	0.60 (0.10-3.47)	0.569	17/17	9.63 (2.59-35.77)	0.009a
Age (yr)
≤ 60	64/60	1.70 (0.97-2.98)	0.064	53/52	5.22 (2.49-10.97)	< 0.001a
> 60	12/15	3.19 (1.00-10.20)	0.045a	26/26	6.47 (2.38-17.59)	< 0.001a
Cirrhosis
Yes	70/69	1.93 (1.15-3.22)	0.012a	17/24	3.50 (0.66-18.47)	0.122
No	6/6	1.73 (0.10-30.65)	0.695	11/28	0.98 (0.19-5.00)	0.979
AFP (ng/mL)
≤ 300	40/39	1.73 (0.77-3.87)	0.179	34/55	2.94 (1.01-8.57)	0.036a
> 300	34/34	2.11 (1.09-4.08)	0.025a	16/16	2.65 (0.60-11.66)	0.226

^aStatistically significant. HR: Hazard ratio; CI: Confidence interval; AFP: Alpha-fetoprotein.