Plasma microRNAs as potential new biomarkers for early detection of early gastric cancer

Figure 2 Expression of the four identified microRNAs between the control (Control-1 + Control-2) and cancer (early gastric cancer + advanced gastric cancer) groups. To assess the diagnostic utility of miR-7641, miR-425-5p, miR-1180-3p and miR-122-5p, a linear combination of the risk score of the four miRNAs weighted by the regression coefficient was used to calculate a risk score factor (RSF) for the four-microRNA panel for each subject. The RSF was calculated as follows: RSF = 1.569 × miR-7641 + 1.312 × miR-425-5p + 1.852 × miR-1180-3p + 1.322 × miR-122-5p. Area under curve = 0.799, 95% confidence interval: 0.691-0.908, P < 0.001. AUC: Area under curve; CI: Confidence interval; miRNA: MicroRNA.