Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection

doi:10.3748/wjg.v25.i13.1566

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2019; 25(13): 1566-1579
Published online Apr 7, 2019. doi: 10.3748/wjg.v25.i13.1566

Table 3 Comparison of hepatitis B virus quasispecies complexity indices between patients with and without liver cirrhosis

	Cirrhotic (n = 5)	Non cirrhotic (n = 19)	P value
nHpl, median (IQR)	34 (28.5-44)	42 (27-60)	0.5456
nMuts, median (IQR)	28 (21-95.5)	100 (50-105)	0.2130
Mf, median (IQR)	0.035 (0.0019-0.0905)	0.03715 (0.0025-0.0440)	0.8311
Pi, median (IQR)	0.0223 (0.00347-0.0445)	0.0434 (0.0044-0.0481)	0.3937
Hill number (q = 1), median (IQR)	10.06 (6.7-18.69)	16.62 (7.02-22.02)	0.4994
Hill number (q = 2), median (IQR)	6.56 (2.81-10.23)	8.37 (3.05-10.42)	0.7223

IQR: Interquartile range; nHpl: Number of haplotypes; nMuts: Number of mutations; Mf: Mutation frequency; Pi: Nucleotide diversity.

Citation: Godoy C, Tabernero D, Sopena S, Gregori J, Cortese MF, González C, Casillas R, Yll M, Rando A, López-Martínez R, Quer J, González-Aseguinolaza G, Esteban R, Riveiro-Barciela M, Buti M, Rodríguez-Frías F. Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection. World J Gastroenterol 2019; 25(13): 1566-1579
URL: https://www.wjgnet.com/1007-9327/full/v25/i13/1566.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i13.1566