Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection

doi:10.3748/wjg.v25.i13.1566

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 7, 2019; 25(13): 1566-1579
Published online Apr 7, 2019. doi: 10.3748/wjg.v25.i13.1566

Table 2 Comparison of hepatitis B virus quasispecies complexity indices between hepatitis B e-antigen-negative and hepatitis B e-antigen-positive chronic hepatitis D patients

	CHD HBeAg-negative (n = 4)	CHD HBeAg-positive (n = 5)	P value
nHpl, median (IQR)	42 (36-47)	42 (27-54)	1.0
nMuts, median (IQR)	97.5 (72.5-104)	100 (18-100)	1.0
Mf, median (IQR)	0.039 (0.027-0.045)	0.035 (0.002-0.041)	0.4127
Pi, median (IQR)	0.047 (0.033-0.052)	0.046 (0.004-0.049)	0.5556
Hill number (q = 1), median (IQR)	17.29 (14.46-20.49)	16.62 (10.06-20.96)	1.0
Hill number (q = 2), median (IQR)	10.03 (8.29-12.11)	8.15 (6.56-10.42)	0.5556

IQR: Interquartile range; CHD: Chronic hepatitis D patients; nHpl: Number of haplotypes; nMuts: Number of mutations; Mf: Mutation frequency; Pi: Nucleotide diversity.

Citation: Godoy C, Tabernero D, Sopena S, Gregori J, Cortese MF, González C, Casillas R, Yll M, Rando A, López-Martínez R, Quer J, González-Aseguinolaza G, Esteban R, Riveiro-Barciela M, Buti M, Rodríguez-Frías F. Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection. World J Gastroenterol 2019; 25(13): 1566-1579
URL: https://www.wjgnet.com/1007-9327/full/v25/i13/1566.htm
DOI: https://dx.doi.org/10.3748/wjg.v25.i13.1566