Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway

Figure 2 Impact of ursodeoxycholic acid on oleic acid-induced production of lipid profile. A: Oil red O staining of oleic acid-induced LO2 cells after ursodeoxycholic acid treatment for 72 h. B-E: Measurement of intracellular levels of triglycerides (B), alanine aminotransferase (C), aspartate aminotransferase (D), and gamma-glutamyl transpeptidase (E) by ELISA assay. Scar bar: 20 μm. Data are shown as the mean ± SE. ^bP < 0.01, ^cP < 0.001 vs ctrl group; ns vs model group. ^dP < 0.001 vs model group. Ctrl: Control; UDCA: Ursodeoxycholic acid; OA: Oleic acid; TG: Triglycerides; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transpeptidase; ns: No significant statistical difference.