Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway

Figure 1 Effect of ursodeoxycholic acid on cell growth ability under the treatment of oleic acid. A: Oil red O staining of LO2 cells after oleic acid (OA) treatment for 72 h. B: Cell viability of OA-induced LO2 cells measured using the MTT assay under the condition of concentration gradient of ursodeoxycholic acid (UDCA) for 48 h. C: Cell viability of LO2 cells measured using the MTT assay under the condition of oleic acid and 2 mmol/L UDCA for 24 h, 48 h, and 72 h. Scar bar: 20 μm. Data are shown as the mean ± SE. ^bP < 0.01, ^cP < 0.001 vs model group. Ctrl: Control; UDCA: Ursodeoxycholic acid; OA: Oleic acid.