Molecular detection of epithelial-mesenchymal transition markers in circulating tumor cells from pancreatic cancer patients: Potential role in clinical practice

Table 4 Correlation between total circulating tumor cell status and clinicopathological factors of patients with pancreatic cancer

		Epithelia CTC (%)			Hybrid CTC (%)			Mesenchymal CTC (%)
		Positive	Negative	P-value	Positive	Negative	P-value	Positive	Negative	P-value
Age (yr)	< 60	24/65	16/42	> 0.9	12/39	28/68	0.18	21/49	19/58	0.19
		(36.9)	(38.1)		(30.8)	(41.2)		(42.9)	(32.8)
	≥ 60	41/65	26/42		27/39	40/68		28/49	39/58
		(63.1)	(61.9)		(69.2)	(58.8)		(57.1)	(67.2)
Gender	Male	37/65	26/42	0.56	24/39	39/68	0.56	28/49	35/58	0.77
		(56.9)	(61.9)		(61.5)	(57.4)		(57.1)	(60.3)
	Female	28/65	16/42		15/39	29/68		21/49	23/58
		(43.1)	(38.1)		(38.5)	(42.6)		(42.9)	(39.7)
Differentiation	Well	6/65	4/42	0.21	4/39	6/68	0.97	5/49	5/58	0.84
		(9.2)	(9.5)		(10.3)	(8.8)		(8.1)	(9.3)
	Moderate	38/65	29/42		24/39	43/68		31/49	36/58
		(58.5)	(69.1)		(61.5)	(63.2)		(64.9)	(60.5)
	Poor	21/65	9/42		11/39	19/68		13/49	17/58
		(32.3)	(21.4)		(28.2)	(28)		(27)	(30.2)
TNM stage	I	4/65	6/42	0.29	3/39	7/68	0.59	1/49	9/58	< 0.01
		(6.1)	(14.3)		(7.7)	(10.3)		(2)	(15.5)
	II	13/65	7/42		9/39	11/68		5/49	15/58
		(20)	(16.7)		(23.1)	(16.2)		(10.2)	(25.9)
	III	30/65	19/42		17/39	32/68		22/49	27/58
		(46.2)	(45.2)		(43.6)	(47.1)		(44.9)	(46.6)
	IV	18/65	10/42		10/39	18/68		21/49	7/58
		(27.7)	(23.8)		(25.6)	(26.4)		(42.9)	(12)
Lymph node metastasis	Negative	25/65	22/42	0.08	18/39	29/68	0.78	24/49(49.0)	23/58	0.26
		(38.5)	(52.4)		(46.2)	(42.6)			(39.7)
	Positive	40/65	20/42		21/39	39/68		25/49	35/58
		(61.5)	(47.6)		(53.8)	(57.4)		(51)	(60.3)
Neural invasion	Negative	22/65	17/42	0.38	18/39	21/68	0.78	17/49	22/58	0.77
		(33.8)	(40.5)		(46.2)	(42.6)		(34.7)	(37.9)
	Positive	43/65	25/42		21/39	39/68		32/49	36/58
		(66.2)	(59.5)		(53.8)	(57.4)		(65.3)	(62.1)
Distant metastasis	Negative	46/65	33/42	0.25	27/39	52/68	0.26	25/49	54/58	< 0.01
		(70.8)	(78.6)		(69.2)	(76.5)		(51)	(93.1)
	Positive	19/65	9/42		12/39	16/68		24/49	4/58
		(29.2)	(21.4)		(30.8)	(23.5)		(49)	(6.9)
Ethnic group	Li ethnic group	8/65	5/42	0.98	5/39	8/68	0.52	5/49	8/58	0.24
		(12.3)	(11.9)		(12.8)	(11.8)		(10.2)	(13.8)
	Han ethnic group	44/65	29/42		25/39	48/68		32/49	41/58
		(67.7)	(69.1)		(64.1)	(70.6)		(65.3)	(70.7)
	Zhuang ethnic group	13/65	8/42		9/39	12/68		12/49	9/58
		(20)	(19)		(23.1)	(17.6)		(24.5)	(15.5)

CTC: Circulating tumor cells.