Molecular detection of epithelial-mesenchymal transition markers in circulating tumor cells from pancreatic cancer patients: Potential role in clinical practice

Table 3 Univariate and multivariate Cox regression analyses of prognostic factors for overall survival in pancreatic cancer

Predictor	Univariate analysis			Multivariate analysis
	HR	95%CI	P-value	HR	95%CI	P-value
Age, < 60 vs ≥ 60	0.818	0.798-1.017	0.792
Gender (female vs male)	0.928	0.781-1.130	0.952
Differentiation (well vs moderate vs poor)	1.045	0.873-1.186	0.134
Ethnic group (Han/Zhuang/Li)	0.917	0.834-1.048	0.866
TNM stage (I/II vs III/IV)	1.452	1.215-1.475	< 0.001	1.148	1.031-1.268	0.011
Lymph node metastasis (negative vs positive)	1.287	1.048-1.364	0.007	1.198	1.036-1.380	0.017
Neural invasion (negative vs positive)	1.008	0.781-1.155	0.949
Distant metastasis (negative vs positive)	1.426	1.236-1.710	< 0.001	1.521	1.256-1.887	< 0.001
CTC, < 6 vs ≥ 6	1.849	1.717-2.238	< 0.001	1.851	1.637-2.173	< 0.001

CTC: Circulating tumor cells.