Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis: A multicenter study in Japan

Table 5 Urinary marker levels at enrollment according to the score of computed tomography Grade by the Japanese Ministry of Health, Labour and Welfare criteria (2008)[15]

Extra-pancreatic progression of inflammation
Score of CT Grade		0	1	2	P value
n		32	8	24
Urinary trypsinogen-2 (mg/dL)	Median	1.26	27.65	16.98	0.001a
	(LQ, UQ)	(0.15, 11.20)	(2.67, 91.61)	(3.04, 71.25)
Urinary trypsinogen-2/cre	Median	3.11	28.5	15.77	0.046a
	(LQ, UQ)	(0.31, 13.17)	(6.70, 130.83)	(3.76, 106.64)
Urinary TAP (ng/mL)	Median	1.97	2.7	4.19	0.001a
	(LQ, UQ)	(0.95, 3.79)	(1.15, 4.73)	(2.55, 8.06)
Urinary TAP/cre (× 0.0001)	Median	2.75	3.65	6.95	0.003a
	(LQ, UQ)	(2.03, 6.53)	(3.10, 4.73)	(4.63, 11.20)
Urinary amylase (× 1000 U/L)	Median	0.94	1.44	2.11	0.06
	(LQ, UQ)	(4.63, 17.14)	(3.13, 41.84)	(8.25, 36.65)
Urinary amylase/cre (U/mg)	Median	2.22	2.02	3.72	0.22
	(LQ, UQ)	(0.85, 3.54)	(0.56, 4.36)	(0.91, 6.15)
Urinary creatinine (× 10 mg/dL)	Median	4.68	6.5	6.7	0.94
	(LQ, UQ)	(3.48, 10.20)	(3.24, 10.14)	(3.95, 9.57)
Serum creatinine (× 0.1 mg/dL)	Median	6.75	6.6	7.5	0.042a
	(LQ, UQ)	(5.88, 8.33)	(4.95, 7.20)	(5.20, 9.00)
Hypo-enhanced lesion of the pancreas
Score of CT Grade		0	1	2	P value
n		55	3	4
Urinary trypsinogen-2 (mg/dL)	Median	4.51	44.33	6.77	0.63
	(LQ, UQ)	(0.47, 30.35)	(1.78, 100.99)	(2.45, 14.81)
Urinary trypsinogen-2/cre	Median	8.37	148.96	9.07	0.84
	(LQ, UQ)	(0.53, 40.84)	(2.27, 179.09)	(6.54, 15.45)
Urinary TAP (ng/mL)	Median	2.61	3.07	5.88	0.45
	(LQ, UQ)	(1.33, 5.63)	(2.79, 5.22)	(1.04, 12.48)
Urinary TAP/cre (× 0.0001)	Median	4.1	6.7	6.85	0.65
	(LQ, UQ)	(2.30, 7.20)	(4.90, 10.30)	(3.25, 11.80)
Urinary amylase (× 1000 U/L)	Median	1.24	1.01	2.22	0.83
	(LQ, UQ)	(4.95, 28.55)	(7.87, 22.70)	(2.94, 35.16)
Urinary amylase/cre (U/mg)	Median	2.59	3.39	2.21	0.72
	(LQ, UQ)	(0.88, 4.56)	(1.00, 4.03)	(0.46, 6.13)
Urinary creatinine (× 10 mg/dL)	Median	6.37	5.64	7.47	0.56
	(LQ, UQ)	(3.70, 10.45)	(2.98, 7.85)	(3.11, 10.53)
Serum creatinine (× 0.1 mg/dL)	Median	6.95	7.8	6.25	0.3
	(LQ, UQ)	(5.83, 8.60)	(4.90, 8.60)	(4.70, 7.88)

Extra-pancreatic progression of inflammation: 0 = anterior pararenal space, 1 = root of mesocolon, 2 = beyond the lower pole of the kidney. Hypoenhanced lesion of the pancreas: The pancreas was divided into three segments. 0 = signal was localized in each segment or only the surrounding pancreas, 1 = covers two segments, 2 = entirely covered two or more segments. Data are expressed as the median (lower quartile, and upper quartile). Statistical significance is expressed as

^aP < 0.05 among the three groups by ordinal logistic regression analysis. LQ: Lower quartile; UQ: Upper quartile; CT: Computed tomography; TAP: Trypsinogen activation peptide.