Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis: A multicenter study in Japan

Table 4 Urinary marker levels at enrollment between patients with severe and mild pancreatitis by computed tomography Grade according to the Japanese Ministry of Health, Labour and Welfare criteria (2008)[15]

	Severity by CT Grade
	Severe		Mild
No. cases	28		42
Score of CT Grade: mean (SD)	2.37 (0.69)		0.17 (0.38)
Extra-pancreatic progression of inflammation (Score 0/1/2)	0/1/27		35/7/0
Hypo-enhanced lesion of the pancreas (Score 0/1/2)	19/3/4		42/0/0
Age: median (LQ, UQ), yr	53 (44, 67)		61 (47.5, 73.25)
Sex: male/female, n	20/6		24/18
	Median (LQ, UQ)				AUC
Urinary trypsinogen-2, mg/dL	14.68	(2.10, 66.90)	2.69	(0.20, 17.11)	0.701
Urinary trypsinogen-2/cre	14.40	(4.29, 104.03)	6.36	(0.32, 17.94)	0.678
Urinary TAP, ng/mL	3.98	(2.20, 7.81)	2.07	(0.96, 3.87)	0.692
Urinary TAP/cre, × 0.0001	6.70	(4.15, 10.90)	3.10	(2.20, 6.00)	0.727
Urinary amylase, × 1000 U/L	1.94	(0.64, 3.62)	0.97	(0.47, 2.29)	0.615
Urinary amylase/cre, U/mg	3.54	(0.63, 5.88)	2.23	(0.88, 3.65)	0.588
Urinary creatinine, × 10 mg/dL	6.55	(3.54, 9.24)	5.54	(3.49, 10.47)	0.472
Serum amylase, × 100 U/L	9.28	(2.88, 15.22)	6.28	(3.91, 11.74)	0.588
Serum lipase, × 100 U/L	8.10	(1.82, 18.49)	6.95	(4.32, 15.73)	0.521
Serum creatinine, × 0.1 mg/dL	7.25	(5.40, 8.90)	6.90	(5.75, 7.95)	0.574

Their area under the curve scores were calculated between severe and mild pancreatitis groups by logistic regression analysis. The cases with no available data were excluded from analysis. All data were showed by median, lower quartile, and upper quartile. AUC: Area under the curve; LQ: Lower quartile; UQ: Upper quartile; CT: Computed tomography; TAP: Trypsinogen activation peptide.