Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis: A multicenter study in Japan

Table 3 Urinary marker levels at enrollment in patients with severe and mild pancreatitis by prognostic factors according to the Japanese Ministry of Health, Labour and Welfare criteria (2008)[15]

	Severity by prognostic factors
	Severe		Mild
No. cases	9		69
Prognostic factors: mean (SD)	2.89	(1.83)	0.57	(0.69)
Age: median (LQ, UQ), yr	48.5	(45, 69.75)	58	(44, 72)
Sex: male/female	5/2		45/24
	Median (LQ, UQ)				AUC
Urinary trypsinogen-2, mg/dL	6.49	(2.41, 208.76)	2.87	(0.22, 19.98)	0.704
Urinary trypsinogen-2/cre	11.2	(2.43, 214.05)	6.36	(0.31, 33.02)	0.592
Urinary TAP, ng/mL	2.68	(2.07, 5.22)	2.79	(1.25, 5.53)	0.458
Urinary TAP/cre, × 0.0001	6.7	(2.40, 11.50)	4.1	(2.25, 7.20)	0.631
Urinary amylase, × 1000 U/L	1.42	(0.50, 3.16)	1.01	(0.40, 2.68)	0.563
Urinary amylase/cre, U/mg	3.65	(0.38, 8.47)	2.22	(0.81, 4.00)	0.58
Urinary creatinine, × 10 mg/dL	3.63	(3.16, 8.65)	6.09	(3.89, 10.24)	0.599
Serum amylase, × 100 U/L	11.37	(2.44, 23.37)	6.38	(3.46, 11.72)	0.581
Serum lipase, × 100 U/L	5.85	(4.41, 13.57)	6.95	(2.46, 16.71)	0.508
Serum creatinine, × 0.1mg/dL	9.7	(5.95, 19.65)	6.75	(5.83, 8.55)	0.676

Their area under the curve scores were calculated between severe and mild pancreatitis groups by logistic regression analysis. The cases with no available data were excluded from analysis. All data were showed by median, lower quartile, and upper quartile. AUC: Area under the curve; LQ: Lower quartile; UQ: Upper quartile; TAP: Trypsinogen activation peptide.