Quantitative and noninvasive assessment of chronic liver diseases using two-dimensional shear wave elastography

Table 5 Cut-off values of liver stiffness assessed with two-dimensional shear wave elastography in various studies

Ref.	Etiologies	Year	Country	Patients, n	≥ F1 (fibrosis)		≥ F2 (significant fibrosis)		≥ F3 (severe fibrosis)		F4 (cirrhosis)
					Cut-off, kPa	AUROC, %	Cut-off, kPa	AUROC, %	Cut-off, kPa	AUROC, %	Cut-off, kPa	AUROC, %
Leung et al[33]	HBV	2013	China	454	6.5	86	7.1	88	7.9	93	10.1	98
Herrmann et al[37]	HBV	2017	Germany	206	NA	NA	7.1	91	8.1	91	11.5	96
Zeng et al[29]	HBV	2014	China	303	NA	NA	7.2	92	9.7	95	11.7	95
Bavu et al[18]	HCV	2011	France	113	NA	NA	9.1	95	10.1	96	13.3	97
Ferraioli et al[20]	HCV	2012	Italy	121	NA	NA	7.1	92	8.7	98	10.4	98
Grgurevic et al[38]	CVH	2015	Croatia	123	NA	NA	8.1	99	NA	NA	10.8	95
Cassinotto et al[46]	NAFLD	2014	France	108	NA	NA	6.3	86	8.3	89	10.5	88
Garcovich et al[47]	NAFLD	2016	Italy	78	5.1	92	6.7	96	NA	NA	NA	NA
Thiele et al[51]	ALD	2016	Denmark	199	NA	NA	10.2	94	NA	NA	16.4	95

2D-SWE: Two-dimensional shear wave elastography; ALD: Alcoholic liver disease; AUROC: Area under the receiver operating characteristic curve; CVH: Chronic viral hepatitis; HBV: Hepatitis B virus; HCV: Hepatitis C virus; LS: Liver stiffness; NA: Not available; NAFLD: Nonalcoholic fatty liver disease.