Prognostic value of lymph nodes count on survival of patients with distal cholangiocarcinomas

Table 5 Stratified analyses of overall and cancer-specific survival according to the number of retrieved LNs for N0 patients

Variable	4-9 retrieved LNs (1-3 retrieved LNs as the reference)				> 9 retrieved LNs (1-3 retrieved LNs as the reference)
	Overall survival		Cancer-specific survival		Overall survival		Cancer-specific survival
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Age, in yr
≤ 70	0.33 (0.13-0.86)	0.023	0.34 (0.13-0.89)	0.030	1.02 (0.49-2.14)	0.940	0.93 (0.46-1.88)	0.848
> 70	0.32 (0.11-0.98)	0.047	0.33 (0.11-1.04)	0.059	0.63 (0.26-1.49)	0.294	0.40 (1.55-1.04)	0.059
Tumor size, in mm
≤ 20	0.55 (0.21-1.46)	0.232	0.61 (0.22-1.68)	0.340	1.34 (0.60-2.97)	0.472	0.96 (0.41-2.23)	0.921
20-50	0.22 (0.07-0.69)	0.010	0.12 (0.03-0.55)	0.007	0.54 (0.24-1.21)	0.134	0.48 (0.21-1.12)	0.090
> 50	-	-	-	-	-	-	-	-
Grade
Well or moderately differentiated	0.56 (0.24-1.30)	0.180	0.47 (0.18-1.20)	0.114	0.99 (0.49-2.01)	0.994	0.74 (0.34-1.62)	0.454
Poorly or undifferentiated	0.23 (0.07-0.79)	0.020	0.26 (0.07-0.89)	0.032	0.69 (0.31-1.58)	0.389	0.75 (0.32-1.78)	0.514
T stage
T1/T2	0.30 (0.11-0.85)	0.024	0.30 (0.09-0.94)	0.039	0.79 (0.39-1.59)	0.501	0.76 (0.36-1.59)	0.467
T3/T4	0.34 (0.13-0.85)	0.022	0.31 (0.12-0.79)	0.016	0.66 (0.31-1.41)	0.285	0.65 (0.30-1.39)	0.267

CI: Confidence interval; HR: Hazard ratio; LNs: Lymph nodes.