Prognostic value of lymph nodes count on survival of patients with distal cholangiocarcinomas

Table 4 Univariate and multivariate survival analyses of factors associated with overall and cancer-specific survival of patients with node-negative distal cholangiocarcinoma

Variable	Overall survival					Cancer-specific survival
	Univariate analysis			Multivariate analysis		Univariate analysis			Multivariate analysis
	3-yr OS	χ2	P value	HR (95%CI)	P value	3-yr OS	χ2	P value	HR (95%CI)	P value
Race		0.82	0.663				0.13	0.939
White	44.3%					46.8%
Black	49.4%					49.4%
Other	40.4%					44.0%
Sex		1.32	0.250				0.77	0.377
Male	39.5%					46.0%
Female	47.0%					49.8%
Age at diagnosis, in yr		3.85	0.049		0.056		2.73	0.097
≤ 70	49.8%			Reference		51.8%
> 70	31.4%			1.51 (0.98-2.33)		35.7%
Marital status		6.30	0.177				6.52	0.163
Married	42.9%					48.5%
Divorced	-					-
Separated or single	31.8%					39.6%
Widowed	46.9%					46.9%
Unknown	-					-
Year of diagnosis		3.41	0.181				4.05	0.131
2004-2010	50.0%					52.1%
2011-2012	36.5%					41.4%
2013-2014	48.8%					54.0%
Tumor size, in mm		7.47	0.058				9.11	0.027		0.036
≤ 20	47.3%					49.6%			Reference
20-50	36.9%					40.0%			1.57 (0.98-2.53)
> 50	0.0%					0.0%			3.08 (1.16-8.21)
Unknown	46.8%					60.8%			0.72 (0.30-1.71)
Grade		9.65	0.021		0.014		12.56	0.005		0.003
Well differentiated	56.8%			Reference		63.3%			Reference
Moderately differentiated	43.5%			1.59 (0.84-2.99)		51.8%			1.44 (0.70-2.97)
Poorly or undifferentiated	26.0%			2.35 (1.24-4.46)		30.5%			2.90 (1.43-5.88)
Unknown	57.0%			0.76 (0.27-2.16)		57.0%			1.14 (0.37-3.50)
T stage		1.35	0.244				4.63	0.031		0.030
T1/T2	48.7%					58.4%			Reference
T3/T4	37.1%					38.7%			1.69 (1.05-2.71)
Surgery type		0.10	0.748				0.23	0.631
Local excision	45.7%					48.2%
Extensive surgery	44.1%					47.0%
Adjuvant radiotherapy		1.64	0.199				1.53	0.215
No/Unknown radiotherapy	48.2%					53.2%
Beam radiation	35.5%					37.2%
Adjuvant chemotherapy		1.31	0.251				1.48	0.222
No/Unknown chemotherapy	46.3%					53.8%
Chemotherapy performed	38.5%					42.1%
No. of LNs retrieved		7.24	0.026		0.013		6.47	0.039		0.008
1-3	35.1%			Reference		40.9%			Reference
4-9	52.3%			0.39 (0.20-0.74)		60.0%			0.32 (0.15-0.66)
> 9	39.3%			0.85 (0.53-1.36)		44.9%			0.62 (0.36-1.07)

CI: Confidence interval; CSS: Cancer-specific survival; HR: Hazard ratio; LNs: Lymph nodes; OS: Overall survival.