Prognostic value of lymph nodes count on survival of patients with distal cholangiocarcinomas

Table 3 Univariate and multivariate survival analyses of factors associated with overall and cancer-specific survival of all patients with distal cholangiocarcinoma

Variables	Overall survival					Cancer-specific survival
	Univariate analysis			Multivariate analysis		Univariate analysis			Multivariate analysis
	3-yr OS	χ2	P value	HR (95%CI)	P value	3-yr OS	χ2	P value	HR (95%CI)	P value
Race		2.22	0.329				1.95	0.377
White	33.3%					36.1%
Black	34.8%					36.9%
Other	38.9%					42.1%
Sex		0.44	0.507				0.54	0.463
Male	35.3%					38.3%
Female	37.7%					40.9%
Age at diagnosis, in yr		1.89	0.387				0.48	0.783
≤ 60	31.2%					35.8%
60-70	39.1%					41.4%
> 70	30.7%					36.8%
Marital status		5.02	0.285				5.98	0.201
Married	37.3%					39.6%
Divorced	-					-
Separated or single	31.4%					35.3%
Widowed	34.1%					-
Unknown	-
Year of diagnosis		1.82	0.402				3.25	0.197
2004-2010	37.3%					41.4%
2011-2012	30.9%					33.2%
2013-2014	-					-
Tumor size, in mm		8.04	0.045		0.230		8.76	0.032		0.249
≤ 20	40.8%			Reference		44.0%			Reference
20-50	29.9%			1.25 (0.94-1.67)		33.2%			1.23 (0.91-1.68)
> 50	0.0%			1.67 (0.86-3.23)		0.0%			1.76 (0.91-3.43)
Unknown	37.7%			0.95 (0.57-1.58)		46.3%			0.96 (0.56-1.65)
Grade		6.77	0.079				6.92	0.074
Well differentiated	48.6%					52.4%
Moderately differentiated	32.6%					38.9%
Poorly or undifferentiated	30.3%					32.6%
Unknown	43.2%					43.2%
T stage		5.57	0.018		0.270		11.16	< 0.001		0.037
T1/T2	44.3%			Reference		51.6%			Reference
T3/T4	29.6%			1.19 (0.87-1.64)		32.6%			1.45 (1.02-2.07)
N stage		10.64	0.001		0.020		12.27	< 0.001		0.022
N0	44.5%			Reference		47.4%			Reference
N1	26.9%			1.40 (1.05-1.86)		30.3%			1.42 (1.05-1.92)
Surgery type		1.20	0.272				0.73	0.393
Local excision	44.0%					45.3%
Extensive surgery	34.4%					37.9%
Adjuvant radiotherapy		0.16	0.683				0.79	0.372
No/Unknown radiotherapy	39.9%					44.3%
Beam radiation	29.5%					30.5%
Adjuvant chemotherapy		1.10	0.293				2.92	0.087
No/Unknown chemotherapy	41.2%					47.5%
Chemotherapy performed	32.2%					33.3%
No. of LNs retrieved		2.91	0.233				3.90	0.141
1-2	23.6%					29.9%
3-6	35.6%					39.4%
> 6	36.0%					39.0%

CI: Confidence interval; HR: Hazard ratio; LNs: Lymph nodes; OS: Overall survival.