Gas chromatography/mass spectrometry based metabolomic study in a murine model of irritable bowel syndrome

Figure 1 Impact of Clostridium butyricum treatment on irritable bowel syndrome mice. A: Comparison of AWR scores between control and IBS groups, as well as between IBS and IBS + C. butyricum groups after WAS exposure (n = 6 per group). ^aP < 0.05; ^bP < 0.01. B: Fecal pellets at various time points during the experiment (n = 6 per group). ^aP < 0.05: IBS vs IBS + C. butyricum; ^bP < 0.01: control vs IBS, control vs IBS + C. buyricum; ^eP < 0.001: control vs IBS. C: Comparison of AWR scores between control and IBS groups, as well as between IBS and IBS + C. butyricum groups following the C. butyricum treatment period (n = 6 per group) ^aP < 0.05; ^bP < 0.01. AWR: Abdominal withdrawal reflex; C. butyricum: Clostridium butyricum; IBS: Irritable bowel syndrome; WAS: Water avoidance stress.