Relaxin influences ileal muscular activity through a dual signaling pathway in mice

Figure 2 Effect of relaxin on smooth muscle cell membrane passive properties and resting membrane potential (RMP) of the mouse ileum. Influence of relaxin on Cm (A), Gm (B), Gm/Cm (C) and RMP (D) alone (RLX) or in the presence of ODQ (ODQ + RLX), 9CPA (9CPA + RLX) or both of them (ODQ + 9CPA + RLX). ^aP < 0.05, ^bP < 0.01, ^eP < 0.001 vs control SMC (Ctr); ^cP < 0.05, ^dP < 0.01, ^fP < 0.001 vs RLX. In each experimental condition, data are mean ± SE from n = 22 cells (11 strips from 5 mice) (one-way ANOVA and Newman-Keuls post-test), RLX: Relaxin; ODQ: Oxadiazolo[4,3-a]-quinoxalin-1-one; 9CPA: 9-cyclopentyladenine.