Gas chromatography/mass spectrometry based metabolomic study in a murine model of irritable bowel syndrome

doi:10.3748/wjg.v24.i8.894

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2018; 24(8): 894-904
Published online Feb 28, 2018. doi: 10.3748/wjg.v24.i8.894

Table 2 Metabolites distinguishing irritable bowel syndrome mice from control mice

Compound	Formula	Similarity	RT (min)	VIP value	P value	Fold change	Trend compared with controls
N-acetyl-D-galactosamine 1	C₈H₁₅NO₆	886	17.1523,0	1.167810623	0.002673237	2.665558179	Down
Myristic acid	C₁₄H₂₈O₂	878	15.2969,0	1.454697623	0.033949959	2.405282471	Down
Arachidic acid	C₂₀H₄₀O₂	837	19.8283,0	2.030221054	0.033823382	0.555519799	Up
1-Hexadecanol	C₁₆H₃₄O	761	16.2434,0	2.137279002	0.03239841	3.735617796	Down
Octadecanol	C₁₈H₃₈O	632	17.7928,0	1.226172539	0.039254153	3.503198671	Down
Phenylethylamine	C₈H₁₁N	764	12.6834,0	1.844742352	0.040836128	0.234956253	Up
2-Furoic acid	C₅H₄O₃	710	7.80292,0	1.057850377	0.044324108	1.829643584	Down
4,2',4'-Trihydroxychalcone	C₁₅H₁₂O₄	245	22.6862,0	1.871154718	0.049356394	0.502503451	Up
24,25-Dihydrolanosterol	C₃₀H₅₂O	593	25.186,0	2.237217404	0.041969612	0.449343275	Up
Androsterone 1	C₁₉H₃₀O₂	476	20.6021,0	1.51415211	0.031210567	2.125877191	Down
Chlorogenic acid 1	C₁₆H₁₈O₉	402	23.8786,0	1.950369158	0.016252537	3.264118801	Down
Cysteinylglycine 2	C₁₀H₁₈N₄O₆S₂	393	16.5878,0	2.464379346	0.003149634	11.06227902	Down
Alpha-tocopherol	C₂₉H₅₀O₂	305	24.0995,0	1.25237824	0.040967864	0.406678915	Up
4-Hydroxybenzoic acid	C₇H₆O₃	811	13.2781,0	1.348316951	0.0129929	2.36224644	Down

IBS: Irritable bowel syndrome; RT: Retention time; VIP: Variable importance in the projection.

Citation: Yu LM, Zhao KJ, Wang SS, Wang X, Lu B. Gas chromatography/mass spectrometry based metabolomic study in a murine model of irritable bowel syndrome. World J Gastroenterol 2018; 24(8): 894-904
URL: https://www.wjgnet.com/1007-9327/full/v24/i8/894.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i8.894