Case Report
Copyright ©The Author(s) 2018.
World J Gastroenterol. Feb 21, 2018; 24(7): 870-875
Published online Feb 21, 2018. doi: 10.3748/wjg.v24.i7.870
Table 1 World Health Organization 2010 classification of combined hepatocholangiocarcinoma
World Health Organization 2010[4]
cHCC-ICC classical: Typical HCC and typical ICC
cHCC-ICC-SC
cHCC-ICC-SC-typical: Nests of mature-looking hepatocytes with peripheral clusters of small cells that have a high nucleus:cytoplasm ratio and hyperchromatic nuclei.
cHCC-ICC SC-int: Tumor cells show features intermediate between hepatocytes and cholangiocytes. These tumor cells show strands, solid nests and/or trabeculae of small, uniform cells with scant cytoplasm and hyperchromatic nuclei.
cHCC-ICC-SC-CLC: Admixtures of small monotonous glands, antler-like anastomosing patterns. Each tumor cell is cuboidal, smaller in size than normal hepatocytes, with a high nucleus: cytoplasm ratio, and distinct nucleoli.