Translational pancreatic cancer research: A comparative study on patient-derived xenograft models

Table 4 Impact of immunohistochemistry on experimental models n (%)

	Human (n = 11)	Subcutaneous (n = 23)	Intraperitoneal (n = 17)	Pancreas (n = 16)	P1 value
Impact of cell proliferation (Ki67)
Mild	4 (36.4)	13 (56.5)	10 (58.8)	8 (50)	0.650
High	7 (63.3)	10 (43.5)	7 (41.2)	8 (50)
Impact of fibrogenesis (α-SMA)
Mild	0 (0)	16 (69.6)	11 (64.7)	14 (87.5)	< 0.001
High	11 (100)	7 (30.4)	6 (35.3)	2 (12.5)
Impact of angiogenesis (CD31)
Mild	2 (18.2)	15 (65.2)	11 (64.7)	14 (87.5)	< 0.001
High	9 (81.8)	8 (34.8)	6 (35.3)	2 (12.5)
Impact of apoptosis (TUNEL)
Mild	3 (27.3)	16 (69.6)	14 (82.4)	15 (93.8)	< 0.001
High	8 (72.7)	7 (30.4)	3 (17.6)	1 (6.3)

¹Statistical analyses were performed by the χ² exact test, with P < 0.05 considered statistically significant. The Bonferroni correction was applied for post hoc analysis. The impact of the immunohistochemistry was assessed by Ki67 expression (cell proliferation), α-SMA expression (fibrogenesis), CD31 expression (angiogenesis) and TUNEL expression (apoptosis).