Inhibitory effects of patchouli alcohol on stress-induced diarrhea-predominant irritable bowel syndrome

Figure 2 Inhibitory effects of patchouli alcohol on the spontaneous and EFS-induced contractions of the isolated colonic longitudinal smooth muscle. A and B: mechanical recording and linear regression curve of the cumulative log concentration-response of PA-induced (3 × 10^-7 mol/L to 1 × 10^-4 mol/L) relaxation of the spontaneous contraction in the colonic longitudinal smooth muscles of the control rats (n = 8; ^bP < 0.01 vs vehicle DMSO group; unpaired t test). C: Relaxation effect of PA on EFS-induced contraction response of the colonic longitudinal smooth muscle in control, IBS-D, and PA-treated (100 μmol/L) IBS-D rats (control group: n = 38, IBS-D group: n = 31, PA-treated IBS-D group: n = 8. ^aP < 0.05 vs control, ^bP < 0.01 vs control, ^dP < 0.01 vs group IBS-D; ANOVA). D: Contraction response to EFS of the jejunal longitudinal smooth muscle (control group: n = 9, IBS-D group: n = 6. ^aP < 0.05 vs control; unpaired t test). Data are expressed as mean ± SE. PA: Patchouli alcohol; EFS: Electrical field stimulation, PA: Patchouli alcohol.