Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population

Figure 3 Sequence logos showing the information content of amino acid positions from the sodium-taurocholate cotransporting polypeptide-interacting domain and the virion morphogenesis domain, in all the haplotypes obtained by next-generation sequencing. In order to simplify variations due to HBV genotype, the numeration of aa positions from both domains is presented according to genotype D: NTCP-interacting domain from residues 2 to 48 of the N-terminal end of preS1, and the virion morphogenesis domain from residues 92 to 108 of the C-terminal end of preS1 and first 5 residues from the N-terminal end of preS2. Positions where the wild-type aa varies according to HBV genotype have been highlighted in bold and red. aa: Amino acid; NTCP: Sodium-taurocholate cotransporting polypeptide.