Copyright
©The Author(s) 2018.
World J Gastroenterol. Feb 7, 2018; 24(5): 549-572
Published online Feb 7, 2018. doi: 10.3748/wjg.v24.i5.549
Published online Feb 7, 2018. doi: 10.3748/wjg.v24.i5.549
Figure 3 The auto-regulatory loop of highly up-regulated in liver cancer through inhibition miRNA-372 in hepatocellular carcinoma.
miR-372 binding to HULC can repress the expression and activity of miR-372. Inhibition of miR-372 leads to a reduction in translational repression of its target gene PRKACB, which in turn induces phosphorylation of CREB, thereby increasing the amount of CREB that can bind to the proximal promoter of HULC to induce HULC expression. HULC: Highly up-regulated in liver cancer.
- Citation: El Khodiry A, Afify M, El Tayebi HM. Behind the curtain of non-coding RNAs; long non-coding RNAs regulating hepatocarcinogenesis. World J Gastroenterol 2018; 24(5): 549-572
- URL: https://www.wjgnet.com/1007-9327/full/v24/i5/549.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i5.549