Behind the curtain of non-coding RNAs; long non-coding RNAs regulating hepatocarcinogenesis

Figure 2 Highly up-regulated in liver cancer interactions with miRNA. Highly up-regulated in liver cancer (HULC) inhibits the actions of miR-6825-5p, miR 6845-5p and miR 6886-3p which modulates the cell sensitivity to chemotherapy and autophagy. Moreover, it inhibits the function of miR-200a-3p hence inducing EMT and metastasis. HULC downregulates miR-107 promoting angiogenesis and tumor proliferation. Overexpression of HULC diminishes miR-203 antitumor effect. While HULC contributes to lipid deregulation and tumor progression through the downregulation of miR-9, ZNFX1-AS1 upregulates miR-9 resulting in tumor suppression HULC and PCAT-14 promote proliferation through the inhibition of miR-372 however through different mechanisms. (-): Inhibits/Downregulates (+): Upregulates. EMT: Epithelia-mesenchymal transition; PCAT: Prostate cancer-associated transcript.