PIK3CA and TP53 mutations predict overall survival of stage II/III colorectal cancer patients

Table 4 Association of PIK3CA functional domain mutations with overall survival in stage II/III CRC patients n (%)

Domain	Alive	Dead	Multivariate HR (95%CI)	P value
Kinase domain
Wild-type	116 (60.42)	76 (39.58)	1 (Ref.)
Mutation	23 (46.94)	26 (53.06)	1.56 (1.00-2.44)	0.052
C2 domain
Wild-type	118 (58.71)	83 (41.29)	1 (Ref.)
Mutation	21 (52.50)	19 (47.50)	1.13 (0.68-1.86)	0.638
Helical domain
Wild-type	110 (59.14)	76 (40.86)	1 (Ref.)
Mutation	29 (52.73)	26 (47.27)	1.30 (0.83-2.05)	0.248
p85 binding domain
Wild-type	127 (57.73)	93 (42.27)	1 (Ref.)
Mutation	12 (57.14)	9 (42.86)	1.05 (0.53-2.08)	0.894
Ras binding domain
Wild-type	123 (58.57)	87 (41.43)	1 (Ref.)
Mutation	16 (51.61)	15 (48.39)	1.27 (0.73-2.20)	0.404

HR: Hazard ratio; 95%CI: 95% confidence interval.