Impact of SNP-SNP interactions of DNA repair gene ERCC5 and metabolic gene GSTP1 on gastric cancer/atrophic gastritis risk in a Chinese population

Table 3 Epistatic effect of pair-wise interacting factors on the risk of atrophic gastritis and gastric cancer

Interacted pair-wise SNPs	Comparison	Subset	AG vs CON		GC vs CON
			P value	OR (95%CI)	P value	OR (95%CI)
ERCC5 rs2094258 interacted with GSTP1 rs1695	ERCC5 rs2094258 GG vs AG + AA	GSTP1 rs1695 AA	0.006	1.523 (1.125-2.062)	0.948	0.989 (0.704-1.388)
		GSTP1 rs1695 GA + GG	0.205	0.766 (0.508-1.157)	0.820	0.951 (0.619-1.462)
	GSTP1 rs1695 AA vs GA + GG	ERCC5 rs2094258 GG	0.148	1.343 (0.901-2.002)	0.808	1.055 (0.685-1.625)
		ERCC5 rs2094258 AG + AA	0.014	0.678 (0.497-0.926)	0.799	1.045 (0.745-1.465)
ERCC5 rs873601 interacted with GSTP1 rs1695	ERCC5 rs873601 GA + GG vs AA	GSTP1 rs1695 AA	0.025	0.678 (0.483-0.952)	0.148	0.756 (0.517-1.105)
		GSTP1 rs1695 GA + GG	0.380	1.230 (0.775-1.951)	0.872	0.961 (0.592-1.560)
	GSTP1 rs1695 AA vs GA + GG	ERCC5 rs873601 GA + GG	0.054	0.758 (0.571-1.005)	0.955	0.991 (0.730-1.346)
		ERCC5 rs873601 AA	0.226	1.356 (0.828-2.222)	0.542	1.183 (0.690-2.027)

All tests were adjusted by age, sex, and H. pylori infection. Statistically significant associations were highlighted in bold (P < 0.05). GC: Gastric cancer; AG: Atrophic gastritis; CON: Controls; ERCC5: Excision repair cross complementing group 5; GSTP1: Glutathione S-transferase pi 1.