Behind the curtain of non-coding RNAs; long non-coding RNAs regulating hepatocarcinogenesis

Table 1 Interplay between long non-coding RNAs and miRNAs

lncRNA	miRNA	Effect/ relationship	Pathway
HULC	miR-6825-5p, miR-6845-5p, miR-6886-3p	Inhibitory	Increasing chemotherapy sensitivity through USP22 and sirt1 levels controlling autophagy
	miR-200a-3p	Inhibitory	Increasing ZEB1 expression, EMT and metastasis
	miR-107	Inhibitory	Upregulates E2F1, activates SPHK1 and angiogenesis
	miR-203	Inhibitory	Inhibits cellular proliferation and induces apoptosis
	miR-9 (ZNFX1-AS1)	Inhibitory	Positive feedback loop of HULC/miR-9/PPARA/ACSL1/HULC for lipid metabolism regulation
	miR-372 (PCAT-14)	Inhibitory	Auto-regulatory loop of CREB/HULC/miR-372/PRKACB/CREB/HULC enhancing cellular proliferation
XIST	miR-181a	Inhibitory	Binds to several binding sites on miR-181a modulating its function
	miR-92b	Inhibitory	Suppresses miR-92b/Smad7 oncogenic axis
	miR-139-5p	Inhibitory	Modulate the miR-139-5p/PDK1/AKT axis
CCAT1	Let-7	Inhibitory	Restoring HMGA2 and c-myc levels and enhancing cell proliferation
	miR-490-3p	Inhibitory	Regulate CDK1 and HCC proliferation
AF113014	miR-20a	Interaction	Regulate Erg2 expression
CRNDE	miR-384	Inhibitory	Enhances expression of NF-κB and p-AKT
DANCR	miR-214, miR-320a, miR-199a	Cancels its effect	Cancels the inhibitory effect they exert on CTNNB1 hence enhancing tumorigenesis
FTX	miR-374a	inhibitory	represses Wnt/β-catenin signaling pathway
	miR-545	interaction	Tumor promotor through activation of PI3K/Akt
GAS5	miR-21	inhibitory	downregulated the vimentin level and the upregulated E-cadherin level
GIHCG	miR-200a/b/429	Inhibitory	Associates with EZH2 and silences miRNA
H19	miR-200	activation	tumor-suppressive by mediating hnRNPU/PCAF/RNAPol II
	miR-675	inhibitory	Activation of the AKT/ GSK-3β/Cdc25A signaling pathway
HOTAIR	miR-1	Inhibitory
	miR-218	Inhibitory	Inhibits P16(lnk4a) and P14(ARF) expression, activates Bmi-1 and tumorigenesis
HOTTIP	miR-192, miR-204	Negative	Inhibit HOTTIP expression, GLS1 and HCC proliferation
	miR-125b	Negative	Inhibits HOTTIP expression and HOXA genes
Linc00052	miR-128, miR-485-3p	Complementary base pairing	Modulating NTRK3 expression
Linc-ROR	miR-145	Inhibitory	Enhances HIF-1α/PDK1 expression
MALAT-1	miR-143-3p	inhibitory	regulated ZEB1 expression
	miR-146b-5p	inhibitory	targeting TRAF6 mediated Akt phosphorylation
MEG-3	miR-29a	interaction	modulate DNMT 1 and 3
	miR-26a	Negative	Modulates miR-26a/DNMT3B/MEG3
NEAT1	miR-129-5p	Inhibitory	Inhibits the miRNA through regulating VCP/IκB, its downstream pathway
lincRNA-p21	miR-9	inhibitory	Tumor suppressive
PCAT-14	miR-372 (HULC)	Inhibitory	Regulates ATAD2 and hedgehog pathway
PTENP1	miR-17, miR-19b, miR-20a	Inhibitory	Inhibiting PIK3T/AKT pathway and inducing autophagy
PVT1	miR-186-5p	Inhibitory	Restores YAP1 expression levels
SNHG1	miR-195	Inhibitory
SNHG6	miR-26a, miR-26b	Inhibitory	Modulate TAK1 expression
SNHG12	miR-199a/b-5p	Inhibitory	ceRNA, Enhancing MLK3 expression and NF-κB pathway
TP73-AS1	miR-200a	Inhibitory	miR-200a dependent HMGB1/RAGE regulation
UCA1	miR-203	interaction	UCA1/miR203/Snail2 signaling pathway regulatory network
	miR-216b	inhibitory	activation of FGFR1/ERK signaling pathway
Unigene56159	miR-140-5p	Inhibitory	ceRNA, Restoring slug expression and EMT
ZNFX1-AS1	miR-9	Positive	Tumor suppression

HOTTIP: HOXA transcript at the distal TIP; lncRNAs: Long non-coding RNAs; PCAT: Prostate cancer-associated transcript; HULC: Highly up-regulated in liver cancer; XIST: X-inactive specific transcript; TCF7: Transcription factor 4; TUG1: Taurine upregulated gene 1; EGFR: Epidermal growth factor receptor; CCAT1: Colon cancer associated transcript 1; MALAT1: Metastasis-associated lung adenocarcinoma transcript 1; UCA1: Urothelial carcinoma-associated 1; SPRY4-IT: Sprouty 4-intron transcript; SNHG: Small nucleolar rna host gene.