Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease

Figure 5 Effect of RIP3 on inflammatory markers. A and B: TNF-α/LPS + zVAD induced increase in TNF-α expression was exacerbated with GSK'843 treatment. TNF-α/LPS + zVAD induced increased expression of CXCL1 and CXCL2 was decreased with GSK'843 treatment. ^aP < 0.05 by ANOVA, Duncan post hoc analysis, compared to control; ^bP < 0.05 by ANOVA, Duncan post hoc analysis. TNF-α: Tumor necrosis factor alpha; LPS: Lipopolysaccharide; zVAD: N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone; CXCL1: Chemokine (C-X-C motif) ligand-1; CXCL2: Chemokine (C-X-C motif) ligand-2; ANOVA, Analysis of variance.